Recombinant Human Tumor Necrosis Factor, His-tagged

• Cat.No.: TNF-379H
• Product Overview: Recombinant HumanTNF-a His produced in E. coli is a single, non-glycosylated, polypeptidechain containing 157 amino acids fragment (77-233) and having a MW 21.85 kDawith an amino-terminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: 77-233 a.a.
• Description: Tumor necrosisfactor-alpha is the best-known member of this class, and sometimes referredto when the term tumor necrosis factor is used. TNF is a monocyte-derivedcytotoxin that has been implicated in tumour regression, septic shock andcachexia.
• Form: Recombinant humanTNF-a-His (0.75 mg/ml) is supplied in 10 mM Tris + 0.1M NaCl + 50% glycerol.
• Purity: Greater than 95.0%as determined by analysis by RP-HPLC and by SDS-PAGE.
• Storage: Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
• OfficialSymbol: TNF
• Pathways: Adipocytokinesignaling pathway; Adipogenesis; African trypanosomiasis; Allograftrejection; Alzheimer" s disease; Amoebiasis; Amyotrophic lateral sclerosis(ALS); Angiopoietin receptor Tie2-mediated signaling; Antigen processing andpresentation; Apoptosis; Asthma; Calcineurin-regulated NFAT-dependenttranscription in lymphocytes; Canonical NF-kappaB pathway; Caspase cascade inapoptosis; Cellular roles of Anthrax toxin; Ceramide signaling pathway

Gene Information

• Gene Name: TNF tumor necrosis factor [ Homosapiens ]
• Synonyms: TNF;tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin;APC1 protein; OTTHUMP00000029281; TNF, monocyte-derived; TNF,macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha;tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member2; Tumornecrosis factor; Cachectin
• Gene ID: 7124
• mRNA Refseq: NM_000594
• Protein Refseq: NP_000585
• MIM: 191160
• UniProt ID: P01375
• Chromosome Location: 6p21.3
• Function: cytokine activity; identicalprotein binding; protease binding; protein binding; transcription regulatoryregion DNA binding; tumor necrosis factor receptor binding