Recombinant Human TTR

Description :	This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Source :	E. coli
Tissue specificity :	Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Form :	Liquid
Purity :	>90% by SDS-PAGE
Storage buffer :	Preservative: NoneConstituents: 10% Glycerol, 20mM HEPES, pH 7.0
Storage :	Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities :	Belongs to the transthyretin family.
Tag :	Non
Full Length :	Full L.

Gene Name	TTR transthyretin [ Homo sapiens ]
Official Symbol	TTR
Synonyms	TTR; transthyretin; PALB, prealbumin, amyloidosis type I; HsT2651;
Gene ID	7276
mRNA Refseq	NM_000371
Protein Refseq	NP_000362
MIM	176300
Uniprot ID	P02766
Chromosome Location	18q12.1
Pathway	Amyloids, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem;
Function	hormone activity; hormone binding; protein binding;