Recombinant Human TSC22 Domain Family, Member 3, His-tagged

• Cat.No.: TSC22D3-7192H
• Product Overview: Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 17.2 kDa.

Specification

• Description: TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT.
• Molecular Mass: 17.2 kDa (157aa) confirmed by MALDI-TOF
• Protein length: 1-134aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: TSC22D3 TSC22 domain family, member 3 [ Homo sapiens ]
• Official Symbol: TSC22D3
• Synonyms: TSC22D3; TSC22 domain family, member 3; delta sleep inducing peptide, immunoreactor , DSIPI; TSC22 domain family protein 3; DIP; GILZ; glucocorticoid induced leucine zipper; hDIP; TSC 22R; TSC-22-like protein; TSC-22 related protein; TSC-22-related protein; DSIP-immunoreactive peptide; DSIP-immunoreactive leucine zipper protein; delta sleep-inducing peptide immunoreactor; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; DSIPI; TSC-22R; DKFZp313A1123
• Gene ID: 1831
• mRNA Refseq: NM_001015881
• Protein Refseq: NP_001015881
• MIM: 300506
• UniProt ID: Q99576
• Chromosome Location: Xq22.3
• Function: sequence-specific DNA binding transcription factor activity