TSC22D3
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Official Full Name
TSC22 domain family, member 3 -
Overview
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
TSC22D3;TSC22 domain family, member 3;TSC22 domain family protein 3;TSC22 domain family 3;TSC22-related inducible leucine zipper 3;TSC22-related-inducible leucine zipper 3;delta sleep inducing peptide, immunoreactor;glucocorticoid-induced leucine zipper protein;long glucocorticoid-induced leucine zipper protein;DIP;Gilz;Dsip1;Tilz3;TSC-22R
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
TSC22D3 involved in several pathways and played different roles in them. We selected most pathways TSC22D3 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC22D3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stimuli-sensing channels | CLCN4,TRPC4A,CLCN4-2,TRPC4B,TRPV3,SLC9B2,SLC9A10,FKBP1B,CLCN1,ANO1 |
| Ion channel transport | ATP1A1A.5,TTYH3B,SRI,CLCN1,TTYH1,BEST4,SLC17A3,CLCN7,ANO4,GABRR2A |
| Transmembrane transport of small molecules | FTH1A,TRPC4B,ANO5,ADD3,RHCG2A,SLC35A3A,SLC29A3,SLC27A4,SLC39A1,CCC2 |
Protein Function
TSC22D3 has several biochemical functions, for example, MRF binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC22D3 itself. We selected most functions TSC22D3 had, and list some proteins which have the same functions with TSC22D3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | SIM1B,TCF25,NFE2,BCL6,RORAB,ZNF311,NR3C2,SIX2,POU2F1A,ZNF573 |
| protein binding | BCL2L1,SNRPF,FBXL12,LEF1,TCF3,NAA38,TPM1,GAGE8,HPSE,TJP1 |
| MRF binding | CREBBP,KDM1A,BHLHE40 |
Interacting Protein
TSC22D3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC22D3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC22D3.
TSC22D1;MTA2;lpd;DCLK2;PLEKHF2;HPCAL4
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References
- Kanthimathi, S; Jahnavi, S; et al. Glucokinase Gene Mutations (MODY 2) in Asian Indians. DIABETES TECHNOLOGY & THERAPEUTICS 16:180-185(2014).
- Kavvoura, FK; Raimondo, A; et al. Reclassification of Diabetes Etiology in a Family With Multiple Diabetes Phenotypes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E1067-E1071(2014).
