Recombinant Human TRIM23

• Cat.No.: TRIM23-30124TH
• Product Overview: Recombinant full length Human TRIM23 with N terminal proprietary tag, 89.25 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 574 amino acids
• Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
• Molecular Weight: 89.250kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MATLVVNKLGAGVDSGRQGSRGTAVVKVLECGVCEDVFSL QGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTD LGDSGVWGLKKNFALLELLERLQNGPIGQYGAAEESIGIS GESIIRCDEDEAHLASVYCTVCATHLCSECSQVTHSTKTL AKHRRVPLADKPHEKTMCSQHQVHAIEFVCLEEGCQTSPL MCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTF TEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEHVPGT AENARSCIRAYFYDLHETLCRQEEMALSVVDAHVREKLIW LRQQQEDMTILLSEVSAACLHCEKTLQQDDCRVVLAKQEI TRLLETLQKQQQQFTEVADHIQLDASIPVTFTKDNRVHIG PKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNV ETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVD SSHRDRISEAHSELAKLLTEKELRDALLLIFANKQDVAGA LSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDW LSRQLVAAGVLDVA

Gene Information

• Gene Name: TRIM23 tripartite motif containing 23 [ Homo sapiens ]
• Official Symbol: TRIM23
• Synonyms: TRIM23; tripartite motif containing 23; ADP ribosylation factor domain protein 1, 64kDa , ARFD1, tripartite motif containing 23; E3 ubiquitin-protein ligase TRIM23; ARD1; RNF46
• Gene ID: 373
• mRNA Refseq: NM_001656
• Protein Refseq: NP_001647
• MIM: 601747
• Uniprot ID: P36406
• Chromosome Location: 5q12.3
• Function: GDP binding; GTP binding; GTPase activity; enzyme activator activity; ligase activity