TRIM23
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Official Full Name
tripartite motif containing 23 -
Overview
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. -
Synonyms
TRIM23;tripartite motif containing 23;ADP ribosylation factor domain protein 1, 64kDa , ARFD1, tripartite motif containing 23;E3 ubiquitin-protein ligase TRIM23;ARD1;RNF46;ADP ribosylation factor domain protein 1;ARF domain protein 1;ARFD1;GTP binding protein ARD 1;N-acetyltransferase ARD1 human homolog of;N-acetyltransferase homolog of S. cerevisiae ARD1;Tripartite motif protein TRIM23;OTTHUMP00000123452;OTTHUMP00000123453;OTTHUMP00000222562;RING finger protein 46;GTP-binding protein ARD-1;tripartite motif-containing 23;tripartite motif-containing pr
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRIM23-3408H | Recombinant Human TRIM23, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| TRIM23-17348M | Recombinant Mouse TRIM23 Protein | Mammalian Cells | Mouse | His |
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| TRIM23-30124TH | Recombinant Human TRIM23 | Wheat Germ | Human | Non | 574 amino acids |
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| TRIM23-4530Z | Recombinant Zebrafish TRIM23 | Mammalian Cells | Zebrafish | His |
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| TRIM23-4956R | Recombinant Rhesus monkey TRIM23 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| TRIM23-6273R | Recombinant Rat TRIM23 Protein | Mammalian Cells | Rat | His |
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| TRIM23-1824HCL | Recombinant Human TRIM23 cell lysate | Human | Non |
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| TRIM23-4770R | Recombinant Rhesus Macaque TRIM23 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| TRIM23-4770R-B | Recombinant Rhesus Macaque TRIM23 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| TRIM23-538HF | Recombinant Full Length Human TRIM23 Protein | In Vitro Cell Free System | Human | Full L. 574 amino acids |
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| TRIM23-5930R | Recombinant Rat TRIM23 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TRIM23-5930R-B | Recombinant Rat TRIM23 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TRIM23-9595M | Recombinant Mouse TRIM23 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TRIM23-9595M-B | Recombinant Mouse TRIM23 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TRIM23 involved in several pathways and played different roles in them. We selected most pathways TRIM23 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TRIM23 has several biochemical functions, for example, GDP binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM23 itself. We selected most functions TRIM23 had, and list some proteins which have the same functions with TRIM23. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | NOD1,SH3GL2,PRKAB2,SH3GL1,C1QTNF2,MUL1A,SOD2,CXADR,GSTM3,RASSF3 |
| GDP binding | RHOA,SRP54B,RAB5B,ARF1,RAB27B,RAB7L1,RAB2A,RAB12,KRAS,RAB7 |
| ubiquitin-protein transferase activity | RNF135,BIRC5,G2E3,TRIM17,ZYG11B,NSMCE1,FBXL14,TNFAIP3,ARIH1,TRIM62 |
| enzyme activator activity | UBA2,SEC14L2,TAB1,PSAPL1,MMP24,HSPB2,DAOA,MMP16,CTSA,DBF4 |
| zinc ion binding | TAB3,GCM1,PCGF5,RBM14B,LIN28A,RNF128A,S100A12,MECR,ADAM22,RNF4 |
| GTP binding | RAB3AA,RAP1AA,RAC3,EEF2A.1,EIF2B1,ARL4AB,RASL10A,EIF2B2,TUBB4A,ADSSL1 |
| protein binding | APOH,KIF23,TXNL4A,ISOC2,SELPLG,SNRPD1,NPM2,DAO,CABP5,PACSIN2 |
| ligase activity | CNOT4,GATB,UBR5,TTLL13,PJA2,ATG10,RNF38,UBE2D1B,TRIP12,CDC34A |
| GTPase activity | IRGE4,TUBA1B,RRAGCB,RAB11A,GNAV1,GNAI1,RRAD,RAB26,GTPBP1L,GFM1 |
Interacting Protein
TRIM23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM23 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM23.
PSMA1;TROAP;BAG1;COX5B
Resources
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References
- Smith, S; Gabhann, JN; et al. Estrogen Receptor alpha Regulates Tripartite Motif-Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY 66:163-172(2014).
- Tateda, K; Okazaki, S; et al. The suppression of TRIM21 and the accumulation of IFN-alpha play crucial roles in the pathogenesis of osteonecrosis of the femoral head. LABORATORY INVESTIGATION 92:1318-1329(2012).
