Recombinant Human TRIB2, GST-tagged

• Cat.No.: TRIB2-24H
• Product Overview: Recombinant full-length human TRIB2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: TRIB2 or tribbles homolog 2 proteins encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB2 protein interacts and modulates the activity of signal transduction pathways in a number of physiological and pathological processes. TRIB2 is regulated by inflammatory stimuli in myeloid (THP-1) cells. TRIB2 can act as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. TRIB2 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription.
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~64 kDa
• Applications: Western Blot
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: TRIB2 tribbles homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: TRIB2
• Synonyms: TRIB2; tribbles homolog 2 (Drosophila); tribbles homolog 2; GS3955; TRB2; C5FW; FLJ57420
• Gene ID: 28951
• mRNA Refseq: NM_021643
• Protein Refseq: NP_067675
• MIM: 609462
• UniProt ID: Q92519
• Chromosome Location: 2p25.1
• Function: ATP binding; NOT nucleotide binding; NOT protein kinase activity; protein kinase inhibitor activity; transcription factor binding; transferase activity, transferring phosphorus-containing groups; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity