Recombinant Human TP53I3, His-tagged

• Cat.No.: TP53I3-30289TH
• Product Overview: Recombinant full length Human PIG3 with N terminal His tag, 352 amino acids with tag, MWt 37.6kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 332 amino acids
• Description: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Molecular Weight: 37.600kDa inclusive of tags
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MLAVHFDKPG GPENLYVKEV AKPSPGEGEV LLKVAASALN RADLMQRQGQ YDPPPGASNI LGLEASGHVA ELGPGCQGHW KIGDTAMALL PGGGQAQYVT VPEGLLMPIP EGLTLTQAAA IPEAWLTAFQ LLHLVGNVQA GDYVLIHAGL SGVGTAAIQL TRMAGAIPLV TAGSQKKLQM AEKLGAAAGF NYKKEDFSEA TLKFTKGAGV NLILDCIGGS YWEKNVNCLA LDGRWVLYGL MGGGDINGPL FSKLLFKRGS LITSLLRSRD NKYKQMLVNA FTEQILPHFS TEGPQRLLPV LDRIYPVTEI QEAHKYMEAN KNIGKIVLEL PQ
• Sequence Similarities: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Gene Information

• Gene Name: TP53I3 tumor protein p53 inducible protein 3 [ Homo sapiens ]
• Official Symbol: TP53I3
• Synonyms: TP53I3; tumor protein p53 inducible protein 3; quinone oxidoreductase PIG3; PIG3
• Gene ID: 9540
• mRNA Refseq: NM_004881
• Protein Refseq: NP_004872
• MIM: 605171
• Uniprot ID: Q53FA7
• Chromosome Location: 2p23.3
• Pathway: Direct p53 effectors, organism-specific biosystem; p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem
• Function: NADPH binding; NADPH:quinone reductase activity; nucleotide binding; oxidoreductase activity; protein homodimerization activity