TP53I3
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Official Full Name
tumor protein p53 inducible protein 3 -
Overview
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] -
Synonyms
TP53I3;tumor protein p53 inducible protein 3;PIG3;quinone oxidoreductase PIG3;p53-induced gene 3 protein;quinone oxidoreductase homolog
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TP53I3 involved in several pathways and played different roles in them. We selected most pathways TP53I3 participated on our site, such as p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53I3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | APAF1,CD82A,ATM,GADD45BB,PIDD1,PTENB,CCNE1,SIAH2L,PPM1DB,CCNE2 |
Protein Function
TP53I3 has several biochemical functions, for example, NADPH binding,NADPH:quinone reductase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53I3 itself. We selected most functions TP53I3 had, and list some proteins which have the same functions with TP53I3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| quinone binding | AOC3,HHIP,NDUFS7,ETFDH,SQRDL,ABP1,HHIPL2,AOC2,AMOTL1,NDUFS2 |
| protein homodimerization activity | ENPP1,TYMS,TNNC1,KIAA1804,PVRL4,CHMP4A,ABCD3,PAFAH1B1,PRDM6,UGT1A6 |
| zinc ion binding | S100A6,RNF166,CBLC,ZMIZ1A,YAF2,DPF3,ZYX,SIAH2L,ZNF2,SH3RF2 |
| NADPH binding | KCNAB1,CBR4,GRHPR,FASN,QDPR,DECR1,CBR3,HMGCR,DHFR,CRYZ |
| NADPH:quinone reductase activity | CRYZ,CRYZL1,ADH4 |
Interacting Protein
TP53I3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53I3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53I3.
EEF1G;UNC119;UBR1;FUNDC2;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
Resources
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References
- Sun, Y; Ho, GH; et al. Down-regulation of Tripartite-motif containing 22 expression in breast cancer is associated with a lack of p53-mediated induction. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441:600-606(2013).
- Goretsky, T; Dirisina, R; et al. p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD. AMERICAN JOURNAL OF PATHOLOGY 181:1306-1315(2012).
