Recombinant Human TOLLIP, His-tagged

• Cat.No.: TOLLIP-29826TH
• Product Overview: Recombinant full-length Human Tollip with a N terminal His tag; 294 amino acids, predicted molecular weight 32.4 kDa

Specification

• Description: This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase.
• Protein length: 294 amino acids
• Conjugation: HIS
• Molecular Weight: 32.400kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 40% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMATTVSTQRGPVYIGELPQDFLRITPTQQQRQVQLDAQAAQQLQYGGAVGTVGRLNITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLRQGKVEDKWYSLSGRQGDDKEGMINLVMSYALLPAAMVMPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVALPPAAVNAQPRCSEEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP
• Sequence Similarities: Belongs to the tollip family.Contains 1 C2 domain.Contains 1 CUE domain.

Gene Information

• Gene Name: TOLLIP toll interacting protein [ Homo sapiens ]
• Official Symbol: TOLLIP
• Synonyms: TOLLIP; toll interacting protein; toll-interacting protein; IL 1RAcPIP
• Gene ID: 54472
• mRNA Refseq: NM_019009
• Protein Refseq: NP_061882
• MIM: 606277
• Uniprot ID: Q9H0E2
• Chromosome Location: 11p
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin-1 signaling, organism-specific biosystem; Signaling by Interleukins, organism-specific biosystem
• Function: Toll-like receptor binding; kinase binding; protein binding; signal transducer activity