TOLLIP
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Official Full Name
toll interacting protein -
Overview
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. -
Synonyms
TOLLIP;toll interacting protein;FLJ33531;IL-1RAcPIP;adapter protein;OTTHUMP00000164471;OTTHUMP00000232257;OTTHUMP00000232258;OTTHUMP00000232259;OTTHUMP00000232262;IL1RAcPIP;TOLIP_HUMAN
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Mammalian cells
- HEK293
- HEK293T
- E. coli
- GST
- His
- His&T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TOLLIP involved in several pathways and played different roles in them. We selected most pathways TOLLIP participated on our site, such as Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOLLIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Toll-like receptor signaling pathway | CD86,FOS,FADD,MAPK12,MAP2K2A,IFNA8,TLR2,TRAF3,TBK1,MAPK10 |
Protein Function
TOLLIP has several biochemical functions, for example, SUMO binding,Toll-like receptor binding,interleukin-1, Type I receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TOLLIP itself. We selected most functions TOLLIP had, and list some proteins which have the same functions with TOLLIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | ARIH1,RPA3,USP13,TRP53,BID,TRAF2,STUB1,MAP1LC3C,SUMO1,GRIK2 |
| ubiquitin conjugating enzyme binding | DCUN1D1,PARK2,UBE2V1,RNF19A,TCHP,FOXL2,RNF144AB,DCUN1D3,RNF14,MARCH6 |
| SUMO binding | HERC2,PML,USP25,USPL1,RPS3,CBX4,TDG |
| interleukin-1, Type I receptor binding | IL1RN |
| signal transducer activity | MRGPRA8,GPR25,OLFR150,COPS2,HTR2CL1,GNA14,CALCRLA,ADRA1BB,GNA11A,MRGPRB8 |
| protein binding | SARM1,CLC,C2orf88,LDOC1,AP3S1,GP9,CCR5,ETV4,SETBP1,YIF1A |
| Toll-like receptor binding | TLR2 |
| kinase binding | SLC2A1,STUB1,CEBPB,PFKM,BCL10,PARK7,TRADD,DLG1,PARK2,CEBPA |
Interacting Protein
TOLLIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOLLIP here. Most of them are supplied by our site. Hope this information will be useful for your research of TOLLIP.
DAZAP2;TOM1;TOM1L1;RBPMS;DAB1
Resources
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References
- Finamore, A; Roselli, M; et al. Lactobacillus amylovorus Inhibits the TLR4 Inflammatory Signaling Triggered by Enterotoxigenic Escherichia coli via Modulation of the Negative Regulators and Involvement of TLR2 in Intestinal Caco-2 Cells and Pig Explants. PLOS ONE 9:-(2014).
- Huang, R; Lv, JJ; et al. Identification, characterization and the interaction of Tollip and IRAK-1 in grass carp (Ctenopharyngodon idellus). FISH & SHELLFISH IMMUNOLOGY 33:459-467(2012).
