Recombinant Human TNNI3 Protein, His-Tagged

• Cat.No.: TNNI3-02H
• Product Overview: Recombinant Human TNNI3 Protein, His-Tagged was expressed in E.coli cell. Recombinant Human TNNI3 protein produced in E.Coli is a full length protein containing a total of 260 amino acids and fused to a 6 His Tag at C-terminus, migrating as a 27kDa band on SDS-PAGE.
  Purified by proprietary chromatographic technique.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 260 aa
• Description: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
• Form: Sterile Filtered clear solution.
• Molecular Mass: 27kDa
• Purity: Protein is >95% pure as determined by 12% PAGE (coomassie staining).
• Usage: LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
• Stability: TNNI3 although stable at 4°C for 1 week, should be stored below -18°C.
  Please prevent freeze thaw cycles.
• Storage Buffer: TNNI3 protein solution in PBS and 25mM arginine.

Gene Information

• Gene Name: TNNI3 troponin I3, cardiac type [ Homo sapiens (human) ]
• Official Symbol: TNNI3
• Synonyms: Troponin I cardiac muscle, Cardiac troponin I, TNNI3, TNNC1, CMH7, RCM1, cTnI, CMD2A, MGC116817.
• Gene ID: 7137
• mRNA Refseq: NM_000363.5
• Protein Refseq: NP_000354.4
• MIM: 191044
• UniProt ID: P19429