Native Human TNNI3 Protein

• Cat.No.: TNNI3-01H
• Product Overview: Human Cardiac Troponin C-I-T Complex Protein produced in Human heart tissue.

Specification

• Species: Human
• Source: Human Cardiac
• Description: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
• Form: Sterile Filtered brown solution.
• Molecular Mass: 75 kDa
• Storage: Store at 4 centigrade if entire vial will be used within 2-4 weeks. Store, frozen at -20 centigrade for longer periods of time.
  For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  Avoid multiple freeze-thaw cycles.
• Storage Buffer: 25 mM TRIS buffer, 0.15 M NaCl, 0.09% sodium azide, pH 7.5.
• Shipping: Ice Packs

Gene Information

• Gene Name: TNNI3 troponin I3, cardiac type [ Homo sapiens (human) ]
• Official Symbol: TNNI3
• Synonyms: Troponin I cardiac muscle; Cardiac troponin I; TNNI3; TNNC1; CMH7; RCM1; cTnI; CMD2A; MGC116817; Troponin C slow skeletal and cardiac muscles; TN-C; TNNC1; TNNC; TNC; CMD1Z
• Gene ID: 7137
• mRNA Refseq: NM_000363
• Protein Refseq: NP_000354
• MIM: 191044
• UniProt ID: P19429