Recombinant Human TNFRSF13B, His-tagged

• Cat.No.: TNFRSF13B-7545H
• Product Overview: Recombinant human TNFRSF13B protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-165aa
• Antigen Description: TNFRSF13B, also known as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). It was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family. It controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
• Molecular Mass: 20.9 kDa(188aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSGLGRS RRGGRSRVDQ EERFPQGLWT GVAMRSCPEE QYWDPLLGTC MSCKTICNHQ SQRTCAAFCR SLSCRKEQGK FYDHLLRDCI SCASICGQHP KQCAYFCENK LRSPVNLPPE LRRQRSGEVE NNSDNSGRYQ GLEHRGSEAS PALPGLKLSA DQVALVYS
• Purity: >90% as determined by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B [ Homo sapiens ]
• Official Symbol: TNFRSF13B
• Synonyms: TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; tumor necrosis factor receptor superfamily member 13B; CD267; TACI; tumor necrosis factor receptor 13B; transmembrane activator and CAML interactor; CVID; CVID2; TNFRSF14B; FLJ39942; MGC39952; MGC133214
• Gene ID: 23495
• mRNA Refseq: NM_012452
• Protein Refseq: NP_036584
• MIM: 604907
• UniProt ID: O14836
• Chromosome Location: 17p11.2
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Syndecan-2-mediated signaling events, organism-specific biosystem
• Function: protein binding; receptor activity