Recombinant Human TMEM173 protein, His-tagged

• Cat.No.: TMEM173-1436H
• Product Overview: Recombinant Human TMEM173 aa. (Leu159~Pro373) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Description: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: 30kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Leu159~Pro373
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >98%
• Applications: SDS-PAGE; WB; ELISA; IP; CoIP; ReporterAssays; Purification; Amine Reactive Labeling.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Concentration: 200μg/mL
• Storage buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Isoelectric Point: 5.8

Gene Information

• Gene Name: TMEM173 transmembrane protein 173 [ Homo sapiens (human) ]
• Official Symbol: TMEM173
• Synonyms: TMEM173; transmembrane protein 173; ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; stimulator of interferon genes protein; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; mitochondrial mediator of IRF3 activation
• Gene ID: 340061
• mRNA Refseq: NM_198282.3
• Protein Refseq: NP_938023.1
• UniProt ID: Q86WV6