TMEM173
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Official Full Name
transmembrane protein 173 -
Overview
STING (MITA/MYPS/TMEM173) is a recently identified adaptor found to be a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA . It is ubiquitously expressed, resides in the ER, and has five transmembrane regions. Detecti -
Synonyms
TMEM173;transmembrane protein 173;FLJ38577;NET23;hMITA;hSTING;mediator of IRF3 activation;endoplasmic reticulum IFN stimulator;stimulator of interferon genes protein;mitochondrial mediator of IRF3 activation;endoplasmic reticulum interferon stim
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Bovine
- Sus scrofa (Pig)
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- HEK293T
- GST
- His
- Myc&DDK
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
TMEM173 involved in several pathways and played different roles in them. We selected most pathways TMEM173 participated on our site, such as RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMEM173 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | CXCL10,TANK,IKBKG,IFNA12,TP-1,IFNA21,RIPK1,SIKE1,TBKBP1,CASP8 |
| Cytosolic DNA-sensing pathway | NFKBIA,IFNA14,IFN-a,CASPA,IFI202B,Ifna11,IFNA21,IFNA6,POLR3H,NFKBIAA |
Protein Function
TMEM173 has several biochemical functions, for example, cyclic-GMP-AMP binding,cyclic-di-GMP binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMEM173 itself. We selected most functions TMEM173 had, and list some proteins which have the same functions with TMEM173. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | SNX9,ODZ4,SLC16A1,SPPL3,FAM109B,CD226,UGT1A6,USF2,TARBP2,IDH1 |
| protein binding | RGS1,AGPAT4,NEGR1,VEGFAA,NTRK1,CLTB,GP1BA,ZC3H10,INVS,ZNF622 |
| protein kinase binding | CLTC,FBXO5,AKAP7,CCNB3,FAM83E,KIF13B,TCTN2,CASP9,DLG1,HSP90AB1 |
| ubiquitin protein ligase binding | KDM4A,USP2,HSPA1A,RNF20,RIPK1,GPI1,UBE2Z,CDKN1A,SCN5A,NEDD8 |
| identical protein binding | CSK,VIM,L1CAM,ROBO1,ADIPOR1,SERPINB1A,PYDC3,MID1,GPSM2,BNIP3L |
| transcription factor binding | E2F4,CTBP1,RELA,ESRRB,MDFI,E2F2,CREBBP,JUN,HOXA7,ARID5A |
Interacting Protein
TMEM173 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMEM173 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMEM173.
MAVS;STAT6;cg(2'5')_pa(3'5')p
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