Recombinant Human TIRAP Protein, MYC/DDK-tagged

• Cat.No.: TIRAP-1117H
• Product Overview: Recombinant human TIRAP protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 23.7 kDa
• Purity: >50 ug/mL as determined by microplate BCA method
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein [ Homo sapiens ]
• Official Symbol: TIRAP
• Synonyms: BACTS1; Mal; MyD88-2; wyatt
• Gene ID: 114609
• mRNA Refseq: NM_001039661
• Protein Refseq: NP_001034750
• MIM: 606252
• UniProt ID: P58753