TIRAP
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Official Full Name
toll-interleukin 1 receptor (TIR) domain containing adaptor protein -
Overview
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. -
Synonyms
TIRAP;toll-interleukin 1 receptor (TIR) domain containing adaptor protein;Toll interleukin 1 receptor (TIR) domain containing adaptor protein;toll/interleukin-1 receptor domain-containing adapter protein;Mal;MyD88 adapter like;wyatt;adapter protein wyatt;adaptor protein Wyatt;MyD88 adapter-like protein;Toll-like receptor adaptor protein;BACTS1;FLJ42305
Recombinant Proteins
- Human
- Cynomolgus
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
- GST
- Avi
- Fc
Involved Pathway
TIRAP involved in several pathways and played different roles in them. We selected most pathways TIRAP participated on our site, such as AGE/RAGE pathway,Activated TLR4 signalling,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | SIGLEC15,POLR3H,CTSB,BTR16,MYO9B,KIF5B,DCTN3,POLR3C,CD200R2,NLRP4C |
| IRAK4 deficiency (TLR2/4) | TLR6 |
| Diseases associated with the TLR signaling cascade | TLR6,TLR10,TICAM1 |
| AGE/RAGE pathway | JAK2,AGER,EGFR,MAPK14,DDOST,LGALS3,CHUK,JUN,ATF2,DIAPH1 |
| Disease | TNKS,TNKS2,CUX1,AP1S1,RDBP,RLBP1,CPSF4,AP2A2,MMAA,RCC1 |
| Activated TLR4 signalling | CREB1,APPB,MAPKAPK2B,SAA1,DUSP7,SIGIRR,JUN,MAP3K8,ALCAMB,DHX9 |
| Hepatitis B | BCL2,CREB3L1,PIK3CA,HSPG2,IFNA21,STAT1,SMAD3,BAD,RB1,CASP8 |
| Diseases of Immune System | TLR6,TLR10 |
Protein Function
TIRAP has several biochemical functions, for example, Toll-like receptor 2 binding,Toll-like receptor 4 binding,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIRAP itself. We selected most functions TIRAP had, and list some proteins which have the same functions with TIRAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | NR6A1,KIT,ZBTB16,PSMD7,CADM4,CECR1,HLCS,ADIPOQ,IKBKG,HMOX1 |
| phosphatidylinositol-4,5-bisphosphate binding | KLHL8,CCDC167,SNX18,PFN2,VIL1,ASAP1,STXBP6L,STXBP6,KCNJ2,LDLRAP1 |
| protein kinase C binding | SDPRB,FEZ1,LDB3,HAND2,DACT1,SQSTM1,HDAC5,AKT1,C1QBP,SDPRA |
| Toll-like receptor 2 binding | TLR1,TLR6 |
| protein binding | SLC2A1,MKRN3,ILF2,EEF1A1,VDR,MED7,TOLLIP,RMI1,ZNF180,NQO2 |
| Toll-like receptor 4 binding | S100A9,SAA3,S100A8 |
| protein binding, bridging | FSCN3,TRIM6,TRIM5,EVPL,COL8A2,MEN1,VPS18,LOR,FLRT2,CUX1 |
| protein heterodimerization activity | UGT1A4,HER11,HOMER1,F11R.1,HIST1H2A9,POU5F3,PAFAH1B3,BHLHE40,MYF6,BCL2A |
Interacting Protein
TIRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of TIRAP.
MYD88;TLR4;IRAK2;LTN1;ARAF;IRAK1;CCDC47;IRAK4
Resources
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References
- Rupasree, Y; Naushad, SM; et al. Association of TLR4 (D299G, T399I), TLR9-1486T < C, TIRAP S180L and TNF-alpha promoter (-1031,-863,-857) polymorphisms with risk for systemic lupus erythematosus among South Indians. LUPUS 24:50-57(2015).
- Israel, L; Arkwright, P; et al. Staphylococcal Disease in Humans with Inherited TIRAP/MAL Deficiency and Impaired Antibody Response to the TLR2 Agonist LTA. JOURNAL OF CLINICAL IMMUNOLOGY 34:S140-S140(2014).
