Recombinant Human TIAM2, His-tagged

• Cat.No.: TIAM2-30624TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1134-1701 of Human TIAM2 with N terminal His tag, 568 amino acids, 80kDa,

Specification

• Description: This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
• Form: Lyophilised:Reconstitution with 153 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: FLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNT LETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKV QKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQR VLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASH INEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMH STVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENC KLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNP AGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTN IVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPV SAKLASSRSLKVLKNSSSNEWTGETGKGTLLDSDEGSL SSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNL IKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDP DVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKA NSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFS VQSLTSVVSEECFYETESHGKS
• Sequence Similarities: Belongs to the TIAM family.Contains 1 DH (DBL-homology) domain.Contains 1 PDZ (DHR) domain.Contains 2 PH domains.Contains 1 RBD (Ras-binding) domain.
• Protein length: 1134-1701 a.a.

Gene Information

• Gene Name: TIAM2 T-cell lymphoma invasion and metastasis 2 [ Homo sapiens ]
• Official Symbol: TIAM2
• Synonyms: TIAM2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; STEF
• Gene ID: 26230
• mRNA Refseq: NM_001010927
• Protein Refseq: NP_001010927
• MIM: 604709
• Uniprot ID: Q8IVF5
• Chromosome Location: 6q25
• Pathway: Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem
• Function: Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; receptor signaling protein activity