TIAM2

  • Official Full Name

    T-cell lymphoma invasion and metastasis 2

  • Overview

    This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    TIAM2;T-cell lymphoma invasion and metastasis 2;T-lymphoma invasion and metastasis-inducing protein 2;STEF;FLJ41865;SIF and TIAM1 like exchange factor;SIF and TIAM1-like exchange factor;T cell lymphoma invasion and metastasis 2;T lymphoma invasion and metastasis inducing protein 2;TIAM 2;TIAM-2;TIAM2_HUMAN;OTTHUMP00000017472;OTTHUMP00000231963;OTTHUMP00000231964;OTTHUMP00000231965;OTTHUMP00000231968;OTTHUMP00000238735;OTTHUMP00000238736

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TIAM2-16771M Recombinant Mouse TIAM2 Protein Mammalian Cells Mouse His
TIAM2-30624TH Recombinant Human TIAM2, His-tagged E.coli Human His 1134-1701 a.a.
TIAM2-4637C Recombinant Chicken TIAM2 Mammalian Cells Chicken His
TIAM2-1780HCL Recombinant Human TIAM2 cell lysate Human Non
TIAM2-1048H Recombinant Human TIAM2 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
TIAM2-517H Recombinant Human TIAM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Tiam2-6425M Recombinant Mouse Tiam2 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
TIAM2-9206M Recombinant Mouse TIAM2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
TIAM2-9206M-B Recombinant Mouse TIAM2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TIAM2 involved in several pathways and played different roles in them. We selected most pathways TIAM2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,Fatty acid, triacylglycerol, and ketone body metabolism,G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell death signalling via NRAGE, NRIF and NADE ITGB3BP,ARHGEF16,MCF2L,ECT2,ARHGEF1A,BCL2L11,ARHGAP4A,ARHGEF9,FGD2,FGD4
    NRAGE signals death through JNK MCF2L,ARHGEF16,ARHGEF18,ARHGEF3,AATF,FGD4A,ARHGAP4,AKAP13,ARHGAP4A,ARHGEF17
    GPCR downstream signaling CXCL11.8,LPAR2B,OR52J3,MCF2L,TRPC7,CCK,CNR1,ARHGEF25,SSTR5,CHRM5
    G alpha (12/13) signalling events ECT2,OBSCN,ARHGEF18A,RHOB,RHOGA,MCF2L,ARHGEF18,FGD4,ARHGEF1A,ADRA1D
    Metabolism KHK,CYP2N13,BRP44,GPC5A,RHAG,COX11,CRAT,GLYATL1,CYGB,CYB5A
    Metabolism of lipids and lipoproteins ARSJ,MTF1,NEU4,GLIPR1,ACSF3,AKR1C4,THEM5,APOC2,TMEM195,SREBF2
    Fatty acid, triacylglycerol, and ketone body metabolism AGPAT1,MED31,ECI1,TMEM195,SIN3B,ELOVL1A,STIL,ACOT11B,MED9,DECR1
    PPARA activates gene expression MED26,ANKRD1,MED29,MED7,G0S2,MED25,SREBF2,GLIPR1,MED9,CTGF

    Protein Function

    TIAM2 has several biochemical functions, for example, GTPase activator activity,Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIAM2 itself. We selected most functions TIAM2 had, and list some proteins which have the same functions with TIAM2. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity RASA1,GDI1,ARHGAP31,RGS6,LLGL2,RASA3,AGAP1,CHML,ALS2CL,ARHGAP35
    Rho guanyl-nucleotide exchange factor activity KALRN,FGD1,RASGRF2,C3A.1,ARHGEF11,QUO,PLEKHG5,ARHGEF6,ABR,ALS2CL
    guanyl-nucleotide exchange factor activity RAPGEF5B,KNDC1,SERGEF,ARHGEF7,ARHGEF7A,DOCK4B,RASGEF1BB,FGD4,RAPGEF4,RIC8B
    receptor signaling protein activity IL4R,TRAIP,NGF,DAXX,CD19,ADCYAP1,NSMAF,IL1RL1,ADRB1,KLK1B3

    Interacting Protein

    TIAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIAM2.

    TK1;H2AFX;ANXA7;DNM2;UFD1L;SH3GL2

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