TIAM2

  • Official Full Name

    T-cell lymphoma invasion and metastasis 2

  • Overview

    This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    TIAM2;T-cell lymphoma invasion and metastasis 2;T-lymphoma invasion and metastasis-inducing protein 2;STEF;FLJ41865;SIF and TIAM1 like exchange factor;SIF and TIAM1-like exchange factor;T cell lymphoma invasion and metastasis 2;T lymphoma invasion and metastasis inducing protein 2;TIAM 2;TIAM-2;TIAM2_HUMAN;OTTHUMP00000017472;OTTHUMP00000231963;OTTHUMP00000231964;OTTHUMP00000231965;OTTHUMP00000231968;OTTHUMP00000238735;OTTHUMP00000238736

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Mammalian Cell
  • E.coli
  • HEK293
  • HEK293T
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TIAM2-16771M Recombinant Mouse TIAM2 Protein Mammalian Cell Mouse His
TIAM2-30624TH Recombinant Human TIAM2, His-tagged E.coli Human His 1134-1701 a.a.
TIAM2-4637C Recombinant Chicken TIAM2 Mammalian Cell Chicken His
TIAM2-1780HCL Recombinant Human TIAM2 cell lysate Human Non
TIAM2-1048H Recombinant Human TIAM2 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
TIAM2-517H Recombinant Human TIAM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Tiam2-6425M Recombinant Mouse Tiam2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
TIAM2-9206M Recombinant Mouse TIAM2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
TIAM2-9206M-B Recombinant Mouse TIAM2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TIAM2 involved in several pathways and played different roles in them. We selected most pathways TIAM2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,Fatty acid, triacylglycerol, and ketone body metabolism,G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NRAGE signals death through JNK ABR,PLEKHG2,AATF,FGD4A,ECT2,MCF2L,ARHGEF16,ARHGEF3,ARHGAP4A,FGD2
    Metabolism of lipids and lipoproteins CHAT,ACOT12,ACSF2,MED15,ARF3,CYP2Y3,AWAT2,CERS5,GLTPD1,MED8
    GPCR downstream signaling KISS1,S1PR3,EDN3,OXGR1A.2,NMBB,OPN1MW2,GPR68,OXGR1A.3,VIP,CCK
    PPARA activates gene expression MED16,CTGF,G0S2,GRHL1,GLIPR1,MED8,MED31,MED26,MED22,MED21
    G alpha (12/13) signalling events ARHGEF1A,ARHGEF18,NET1,ABR,ADRA1B,ARHGEF9,ARHGAP4A,PLEKHG2,ITSN1,OBSCN
    Cell death signalling via NRAGE, NRIF and NADE ITGB3BP,KALRNB,DCLRE1B,ECT2,OBSCN,AKAP13,ARHGEF16,ARHGEF3,ITSN1,ARHGAP4A
    Fatty acid, triacylglycerol, and ketone body metabolism PPARGC1B,SIN3B,Agmo,ACOT9.1,MED7,MED10,MED8,MED31,ACOT7,APOA5
    Metabolism PDK2B,CYP2R1,SLC19A2,PDP1,TREH,GLYATL2,SULT1ST6,COX18,FABP12,SCO1

    Protein Function

    TIAM2 has several biochemical functions, for example, GTPase activator activity,Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIAM2 itself. We selected most functions TIAM2 had, and list some proteins which have the same functions with TIAM2. You can find most of the proteins on our site.

    Function Related Protein
    receptor signaling protein activity DOK5,RGS12,IFITM1,CD19,DOK1,DOK4,KLK1B4,DOK2,KLK1B3,FLRT1
    GTPase activator activity AGAP1,PLEKHG6,RGS5,RIN1,ARHGEF19,ARHGAP19,RABEP2,RGS17,ARHGAP29,ARHGEF1
    Rho guanyl-nucleotide exchange factor activity ARHGEF1B,TRIO,ARHGEF1A,RASGRF2,ARHGEF19,ITSN2B,FARP2,RASGRF2B,PLEKHG6,ARHGEF25
    guanyl-nucleotide exchange factor activity RAPGEFL1,FGD6,BCAR3,RASGEF1BA,DOCK6,RAPGEF3,TBXA2R,PRSS56,RAPGEF4,RAPGEF1B

    Interacting Protein

    TIAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIAM2.

    TK1;H2AFX;ANXA7;DNM2;UFD1L;SH3GL2

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