Recombinant Human TIA1 cytotoxic granule-associated RNA binding protein-like 1, His-tagged

• Cat.No.: TIAL1-683H
• Product Overview: TIAL1, 1-375aa Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-375 a.a.
• Description: TIAL1 is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. Recombinant human TIAL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Form: Liquid. In Phosphate buffered saline (pH7.4) containing, 50% glycerol, 2mM DTT, 1mM EDTA
• Molecular Mass: 44.0kDa (398aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMMEDDGQ PRTLYVGNLS RDVTEVLILQ LFSQIGPCKS CKMITEHTSN DPYCFVEFYE HRDAAAALAA MNGRKILGKE VKVNWATTPS SQKKDTSNHF HVFVGDLSPE ITTEDIKSAF APFGKISDAR VVKDMATGKS KGYGFVSFYN KLDAENAIVH MGGQWLGGRQ IRTNWATRKP PAPKSTQENN TKQLRFEDVV NQSSPKNCTV YCGGIASGLT DQLMRQTFSP FGQIMEIRVF PEKGYSFVRF STHESAAHAI VSVNGTTIEG HVVKCYWGKE SPDMTKNFQQ VDYSQWGQWS QVYGNPQQYG QYMANGWQVP PYGVYGQPWN QQGFGVDQSP SAAWMGGFGA QPPQGQAPPP VIPPPNQAGY GMASYQTQ
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 [ Homo sapiens ]
• Official Symbol: TIAL1
• Synonyms: TIAL1; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA1 cytotoxic granule associated RNA binding protein like 1; nucleolysin TIAR; TIAR; T-cluster binding protein; TIA-1-related nucleolysin; aging-associated gene 7 protein; TCBP; MGC33401
• Gene ID: 7073
• mRNA Refseq: NM_001033925
• Protein Refseq: NP_001029097
• MIM: 603413
• UniProt ID: Q01085
• Chromosome Location: 10q
• Function: RNA binding; nucleic acid binding; nucleotide binding