Recombinant Human TGM1 protein, His & GST-tagged

• Cat.No.: TGM1-1781H
• Product Overview: Recombinant Human TGM1 aa. (Ala496~Arg760 (Accession # P22735)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).
• Source: E. coli
• Species: Human
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 61.1kDa.
• Protein length: Ala496~Arg760
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 6.4.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: TGM1 transglutaminase 1 [ Homo sapiens (human) ]
• Official Symbol: TGM1
• Synonyms: Tap2; transporter 2, ATP binding cassette subfamily B member; Cim; Abcb3; antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; Transporter 2 ABC (ATP binding cassette); transporter 2 ATP-binding cassette sub-family B; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
• Gene ID: 7051
• mRNA Refseq: NM_000359.2
• Protein Refseq: NP_000350.1
• UniProt ID: P22735