TGM1
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Official Full Name
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) -
Overview
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3 UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). -
Synonyms
TGM1;transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase);ICR2;protein-glutamine gamma-glutamyltransferase K;LI;LI1;TGASE;TGK;TG(K);TGase K;TGase-1;epidermal TGase;transglutaminase K;transglutaminas
Recombinant Proteins
- Mouse
- Dog
- Human
- Rat
- Rabbit
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- His
- His&GST
- Non
- GST
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
TGM1 involved in several pathways and played different roles in them. We selected most pathways TGM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TGM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TGM1 has several biochemical functions, for example, metal ion binding,protein binding,protein-glutamine gamma-glutamyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TGM1 itself. We selected most functions TGM1 had, and list some proteins which have the same functions with TGM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EIF2AK3,PYGO2,USP47,HK2,VEGFC,CWC22,CXCR4,EHD1,CALU,KPNA3 |
| metal ion binding | TIMM8B,RBM22,DPYD,ARSG,RAF1A,ENDOG,CSH1,NR1D1,POLI,PRKCBB |
| protein-glutamine gamma-glutamyltransferase activity | TGM1L4,TGM4,TGM2A,TGM5,EPB4.2,TGM3,F13A1A.1,F13A1,EPB42,TGM2 |
Interacting Protein
TGM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGM1.
f q l k v p a a v w;yeqhklpsswpf;ALOX12B;Ttk;ALOXE3;RIN3;polg_hcvjf_rna;GABARAPL2;GABARAPL1
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