Description :	Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Source :	HEK293 cells
Species :	Human
Applications :	ELISA, CLIA, CG
Notes :	For research use only, not for use in diagnostic procedure.
Storage :	Short term (up to 7 days) store at 2–8 centigrade. Long term, store at - 20 centigrade. Avoid multiple freeze/thaw cycles.
Storage Buffer :	Supplied as a 0.2 μm filtered solution of PBS, pH7.4

Gene Name	TG thyroglobulin [ Homo sapiens (human) ]
Official Symbol	TG
Synonyms	TG; thyroglobulin; AITD3; TGN;
Gene ID	7038
mRNA Refseq	NM_003235
Protein Refseq	NP_003226
MIM	188450
UniProt ID	P01266

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