Recombinant Human TFE3 Protein, His-tagged

• Cat.No.: TFE3-2761H
• Product Overview: Recombinant Human TFE3 Protein (Met1-Asn350) with a N-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: Met1-Asn350
• Description: This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 40.7 kDa
  Accurate Molecular Mass: 45 kDa
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: TFE3 transcription factor binding to IGHM enhancer 3 [ Homo sapiens (human) ]
• Official Symbol: TFE3
• Synonyms: TFE3; transcription factor binding to IGHM enhancer 3; transcription factor E3; bHLHe33; member A; TFEA; transcription factor E family; Transcription factor for IgH enhancer; transcription factor E family, member A; class E basic helix-loop-helix protein 33; RCCP2; RCCX1
• Gene ID: 7030
• mRNA Refseq: NM_006521
• Protein Refseq: NP_006512
• MIM: 314310
• UniProt ID: P19532