TFE3
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Official Full Name
transcription factor binding to IGHM enhancer 3 -
Overview
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] -
Synonyms
TFE3;transcription factor binding to IGHM enhancer 3;TFEA;RCCP2;RCCX1;bHLHe33;transcription factor E3;transcription factor for IgH enhancer;transcription factor E family, member A;class E basic helix-loop-helix protein 33;transcription factor for immunoglobulin heavy-chain enhancer 3
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TFE3 involved in several pathways and played different roles in them. We selected most pathways TFE3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | MLLT1,HOXA10,TP53,SP1,HIST1H3E,NUPR1,IL2RB,NGFR,RUNX2,HMGA2 |
Protein Function
TFE3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein dimerization activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFE3 itself. We selected most functions TFE3 had, and list some proteins which have the same functions with TFE3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | RCOR2,PPARD,SOX32,PBX1,FOXK2,ETS2,FOXE1,NTNG1,TCF25,GATA2B |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | IRF1,NEUROD1,MYF5,ZNF460,EBF1,HHEX,STAT3,OTX2,NFIB,ZNF257 |
| transcription regulatory region DNA binding | HNF1A,FOXM1,XRCC6,TCF7L1B,IKZF2,TA,TAF9,PROX1,ARRB1,FOXA3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MZF1,MITFA,FOXI1,NUCKS1,E2F4,ELK1,CDX4,TCF21,SOX12,POU2F2 |
| protein dimerization activity | MEF2AA,TCF23,FIGLA,HPS1,HER4.2,GRIN2A,EBF2,MESPBA,HEY2,MESPBB |
Interacting Protein
TFE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TFE3.
PFAS;NUP155;SMC2;EPRS;AKR1B1;GSTM3;PSMA1;PSMA3;VARS;ECHS1;RPA3;LRPPRC;NASP;SMS;ACLY
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References
- Moch, H; Montironi, R; et al. Oncotargets in Different Renal Cancer Subtypes. CURRENT DRUG TARGETS 16:125-135(2015).
- Cykowski, MD; Hicks, J; et al. Brain Metastasis of Crystal-Deficient, CD68-Positive Alveolar Soft Part Sarcoma: Ultrastructural Features and Differential Diagnosis. ULTRASTRUCTURAL PATHOLOGY 39:69-77(2015).
