Recombinant Human TARDBP, DDK-tagged

• Cat.No.: TARDBP-36H
• Product Overview: Recombinant Human TARDBP, fused with C-terminal DDK tag, was expressed in Sf9 cells.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Flag
• Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
• Molecular Mass: 45 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Gene Information

• Gene Name: TARDBP?TAR DNA binding protein [?Homo sapiens?(human) ]
• Official Symbol: TARDBP
• Synonyms: TARDBP; TDP-43; TAR DNA binding protein; ASL 10; TAR DNA-binding protein 43; TDP43; TAR DNA-binding protein 43; OTTHUMP00000002173; TRA DNA-binding protein-43
• Gene ID: 23435
• mRNA Refseq: NM_007375
• Protein Refseq: NP_031401
• MIM: 605078
• UniProt ID: Q13148
• Chromosome Location: 1p36.22
• Function: RNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; double-stranded DNA binding