Recombinant Human TAP2 cell lysate

• Cat.No.: TAP2-1736HCL

Specification

• Species: Human
• Tag: Non
• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [ Homo sapiens ]
• Official Symbol: TAP2
• Synonyms: TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); ABCB3; antigen peptide transporter 2; D6S217E; PSF2; RING11; ABC transporter, MHC 2; peptide supply factor 2; peptide transporter PSF2; peptide transporter TAP2; really interesting new gene 11 protein; transporter 2, ABC (ATP binding cassette); peptide transporter involved in antigen processing 2; ATP-binding cassette, sub-family B (MDR/TAP), member 3; APT2; ABC18; PSF-2
• Gene ID: 6891
• mRNA Refseq: NM_000544
• Protein Refseq: NP_000535
• MIM: 170261
• UniProt ID: Q03519
• Chromosome Location: 6p21.3
• Pathway: ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem
• Function: ATP binding; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; MHC class I protein binding; TAP1 binding; TAP1 binding; TAP2 binding; nucleotide binding; oligopeptide-transporting ATPase activity; peptide antigen binding; peptide antigen-transporting ATPase activity; peptide transporter activity; contributes_to peptide transporter activity; protein binding; tapasin binding; transporter activity; transporter activity