TAP2
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Official Full Name
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. -
Synonyms
TAP2;transporter 2, ATP-binding cassette, sub-family B (MDR/TAP);APT2;PSF2;ABC18;ABCB3;RING11;D6S217E;antigen peptide transporter 2;PSF-2;OTTHUMP00000029078;OTTHUMP00000218770;ABC transporter, MHC 2;peptide supply factor 2;peptide transporter TAP2;really interesting new gene 11 protein;peptide transporter involved in antigen processing 2
Recombinant Proteins
- Mouse
- Rat
- Chicken
- Human
- Mammalian Cells
- E.Coli/Yeast
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAP2-16421M | Recombinant Mouse TAP2 Protein | Mammalian Cells | Mouse | His |
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| Tap2-3513R | Recombinant Rat Tap2, His-tagged | E.Coli/Yeast | Rat | His | 703 |
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| TAP2-3722C | Recombinant Chicken TAP2 | Mammalian Cells | Chicken | His |
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| TAP2-5927R | Recombinant Rat TAP2 Protein | Mammalian Cells | Rat | His |
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| TAP2-7880H | Recombinant Human TAP2 protein, His & T7-tagged | E.coli | Human | His&T7 | Val468~Leu686 |
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| Tap2-7881R | Recombinant Rat Tap2 protein, His & T7-tagged | E.coli | Rat | His&T7 | Arg467~Ala7036 |
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| TAP2-1736HCL | Recombinant Human TAP2 cell lysate | Human | Non |
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| TAP2-5586R | Recombinant Rat TAP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| TAP2-5586R-B | Recombinant Rat TAP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TAP2-660H | Recombinant Human TAP2 Protein, GST-tagged | Wheat Germ | Human | GST | 1-686 aa |
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| TAP2-6806HF | Recombinant Full Length Human TAP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 686 amino acids |
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| TAP2-8986M | Recombinant Mouse TAP2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| TAP2-8986M-B | Recombinant Mouse TAP2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TAP2 involved in several pathways and played different roles in them. We selected most pathways TAP2 participated on our site, such as ABC transporters,Phagosome,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ACTB1,ATP6V1G2,RAB5B,RAC1B,DYNC1I2A,SEC22BB,BLA,ATP6V0E,PIKFYVE,Itgam&Itgb2 |
| Herpes simplex infection | TTC6,HLA-E,HCFC1,IFNGR1,C3A.1,Hc,DAXX,CD74A,SRSF7B,NFKBIA |
| ABC transporters | TAP1,ABCB1,ABCD1,ABCA6,ABCB1LB,CFTR,ABCC5,Abca2,ABCB9,ABCA7 |
| nodeficiency | CD40,TNFRSF13B,BLNK,ZAP70,IKBKG,AICDA,BTK,IL2RG,AIRE,CD8B |
| Antigen processing and presentation | RFX5,HSP90AA1,KLRC2,PSME2,TNF,HLA-DQA1,HSPA2,TAPBP,HSPA1L,KLRC3 |
| Primary i | CD3E,UNG,DCLRE1C,TAP1,CD8A,RFXANK,Cd79a,CD8B1,RAG2,PTPRC |
Protein Function
TAP2 has several biochemical functions, for example, ATP binding,MHC class Ib protein binding,TAP1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAP2 itself. We selected most functions TAP2 had, and list some proteins which have the same functions with TAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | HLA-F,TAP1,TAPBP |
| MHC class Ib protein binding | TAP1,LILRB2 |
| contributes_to peptide transporter activity | TAP1 |
| peptide antigen-transporting ATPase activity | TAPBP |
| protein binding | PDE6H,Anks6,VARS2,RABGAP1,TFDP2,FAM103A1,SNAI2,ABLIM1,ZNF212,SNAP29 |
| ATP binding | PIF1,PRKCQ,KIF3C,DDX11,CSNK2A2,TNIK,MAPK3,KIF27,MKKS,HSP90AA1.2 |
| transporter activity | SLC13A1,FXYD2,AP2S1,PPIAL4A,CSN1S1,SLCO1A6,MIPB,TCIRG1,MUP20,SLCO1B2 |
| tapasin binding | TAP1 |
Interacting Protein
TAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAP2.
TAP1;TAPBP
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References
- Niu, G; Ma, J; et al. The Hierarchical Importance of Components of The Peptide-loading Complex. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 41:904-915(2014).
- Tuncel, J; Haag, S; et al. Natural Polymorphisms in Tap2 Influence Negative Selection and CD4 : CD8 Lineage Commitment in the Rat. PLOS GENETICS 10:-(2014).
