Recombinant Human TAF1C, His-tagged

• Cat.No.: TAF1C-30935TH
• Product Overview: Recombinant fragment, corresponding to amino acids 247-742 of Human TAF1C Isoform 2 with N terminal His tag; Predicted MWt 55 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 247-742 a.a.
• Description: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Conjugation: HIS
• Form: Lyophilised:Reconstitute with 163 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: TGISLSPHLPGELAICSRSGAVCLWSPEDGLRQIYRDPET LVFRDSSSWRWADFTAHPRVLTVGDRTGVKMLDTQGPP GCGLLLFRLGAEASCQKGERVLLTQYLGHSSPKCLPPT LHLVCTQFSLYLVDERLPLVPMLKWNHGLPSPLLLARL LPPPRPSCVQPLLLGGQGGQLQLLHLAEGASVPRLAGPPQSLPSRIDSLPAFPLLEPKIQWRLQERLKAPTIGLAAVV PPLPSAPTPGLVLFQLSAAGDVFYQQLRPQVDSSLRRD AGPPGDTQPDCHAPTASWTSQDTAGCSQWLKALLKVPL APPVWTAPTFTHRQMLGSTELRREEEEGQRLGVLRKAM ARGQLLLQRDLGSLPAAEPPPAPESGLEDKLSERLGEAWAGRGAAWWERQQGRTSEPGRQTRRPKRRTQLSSSFSLSG HVDPSEDTSSPHSPEWPPADALPLPPTTPPSQELTPDA CAQGVPSEQRQMLRDYMAKLPPQRDTPGCATTPP

Gene Information

• Gene Name: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa [ Homo sapiens ]
• Official Symbol: TAF1C
• Synonyms: TAF1C; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; TATA box binding protein (TBP) associated factor, RNA polymerase I, C, 110kD; TATA box-binding protein-associated factor RNA polymerase I subunit C; MGC:39976; SL1; TAFI
• Gene ID: 9013
• mRNA Refseq: NM_001243156
• Protein Refseq: NP_001230085
• MIM: 604905
• Uniprot ID: Q15572
• Chromosome Location: 16q24
• Pathway: RNA Polymerase I Chain Elongation, organism-specific biosystem; RNA Polymerase I Promoter Clearance, organism-specific biosystem; RNA Polymerase I Promoter Escape, organism-specific biosystem; RNA Polymerase I Transcription, organism-specific biosystem; RNA Polymerase I Transcription Initiation, organism-specific biosystem
• Function: DNA binding