Recombinant Human SYT11 protein, His-tagged

• Cat.No.: SYT11-48H
• Product Overview: Recombinant human SYT11, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: SYT11 also known as synaptotagmin-11. The protein may be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. A synaptotagmin potentially involved in Parkinson´s desease and schizophrenia.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In Phosphate Buffered Saline (pH7.4) containing 50% glycerol
• Molecular Mass: 47kDa (418aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSWSCCHQQ AEKKQKNPPY KFIHMLKGIS IYPETLSNKK KIIKVRRDKD GPGREGGRRN LLVDAAEAGLLSRDKDPRGP SSGSCIDQLP IKMDYGEELR SPITSLTPGE SKTTSPSSPE EDVMLGSLTF SVDYNFPKKA LVVTIQEAHG LPVMDDQTQG SDPYIKMTIL PDKRHRVKTR VLRKTLDPVF DETFTFYGIP YSQLQDLVLH FLVLSFDRFS RDDVIGEVMV PLAGVDPSTG KVQLTRDIIKRNIQKCISRG ELQVSLSYQP VAQRMTVVVL KARHLPKMDI TGLSGNPYVK VNVYYGRKRI AKKKTHVKKC TLNPIFNESF IYDIPTDLLP DISIEFLVID FDRTTKNEVV GRLILGAHSV TASGAEHWRE VCESPRKPVA KWHSLSEY
• Purity: >80% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: SYT11 synaptotagmin XI [ Homo sapiens ]
• Official Symbol: SYT11
• Synonyms: SYT11; synaptotagmin XI; synaptotagmin-11; DKFZp781D015; KIAA0080; MGC10881; MGC17226; synaptotagmin 12; SYT12; sytXI
• Gene ID: 23208
• mRNA Refseq: NM_152280
• Protein Refseq: NP_689493
• MIM: 608741
• UniProt ID: Q9BT88
• Chromosome Location: 1q22
• Function: calcium ion binding; calcium-dependent phospholipid binding; protein binding; transporter activity