Recombinant Human SYNE2 Protein (Glu6-Ala264), His tagged

• Cat.No.: SYNE2-5767H
• Product Overview: Recombinant human SYNE2 (Glu6-Ala264) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Glu6-Ala264
• Description: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 28.65 kDa
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SYNE2 spectrin repeat containing, nuclear envelope 2 [ Homo sapiens (human) ]
• Official Symbol: SYNE2
• Synonyms: SYNE2; spectrin repeat containing, nuclear envelope 2; nesprin-2; DKFZP434H2235; KIAA1011; Nesprin 2; NUA; NUANCE; SYNE 2; nesprin 2; polytrophin; synaptic nuclei expressed gene 2; synaptic nuclear envelope protein 2; nuclear envelope spectrin repeat protein 2; nucleus and actin connecting element protein; EDMD5; TROPH; SYNE-2; Nesprin-2; FLJ11014; FLJ43727; FLJ45710; FLJ46790; DKFZp434H2235; DKFZp686H1931; DKFZp686E01115
• Gene ID: 23224
• mRNA Refseq: NM_015180
• Protein Refseq: NP_055995
• MIM: 608442
• UniProt ID: Q8WXH0