Recombinant Human SUN2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: SUN2-1989H
• Product Overview: SUN2 MS Standard C13 and N15-labeled recombinant protein (NP_056189) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: SUN1 and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 80.1 kDa
• AA Sequence: MSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESLVHESWFPPRSSLEELHGDANWGEDLRVRRRRGTGGSESSRASGLVGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVSRAGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPLLLLTCLTYGAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRVMSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGGGGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAHTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: SUN2 Sad1 and UNC84 domain containing 2 [ Homo sapiens (human) ]
• Official Symbol: SUN2
• Synonyms: SUN2; Sad1 and UNC84 domain containing 2; unc 84 homolog B (C. elegans), UNC84B; SUN domain-containing protein 2; rab5IP; unc-84 homolog B; nuclear envelope protein; protein unc-84 homolog B; rab5-interacting protein; sad1/unc-84 protein-like 2; Sad1 unc-84 domain protein 2; UNC84B; KIAA0668; MGC133055; MGC133056
• Gene ID: 25777
• mRNA Refseq: NM_015374
• Protein Refseq: NP_056189
• MIM: 613569
• UniProt ID: Q9UH99