SUN2

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  • Overview
  • Review / Q&A

  • Official Full Name

    Sad1 and UNC84 domain containing 2

  • Overview

    UNC84B (Protein UNC-84 homolog B or SUN2),Is a single-pass nuclear envelope transmembrane protein responsible for nuclear migrations that are essential for development. UNC-84B has a predicted transmembrane domain and a C-terminal region with similarity to the S. pombe spindle pole body protein Sad1. UNC-84B interacts with RAB5A and is widely expressed, and highly expressed in the heart, lungs and muscles. UNC-84 may function to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage.

  • Synonyms

    SUN2;Sad1 and UNC84 domain containing 2;unc 84 homolog B (C. elegans) , UNC84B;SUN domain-containing protein 2;rab5IP;unc-84 homolog B;nuclear envelope protein;protein unc-84 homolog B;rab5-interacting protein;sad1/unc-84 protein-like 2;Sad1 unc-84 domain protein 2;UNC84B;KIAA0668;MGC133055;MGC133056

Recombinant Proteins

  • Mouse
  • Mus musculus
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • DDK
  • Myc
  • Avi
  • Fc

Involved Pathway

SUN2 involved in several pathways and played different roles in them. We selected most pathways SUN2 participated on our site, such as Meiotic Synapsis,Mus musculus biological processes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Meiotic synapsis STAG2,FKBP6,SYNE1,SYCP2,TINF2,TERF2,TEX12,ACD,SYCE1,SYCP1
Mus musculus biological processes MED11,KLF5,SYCE2,POT1A,SYNE2,SYCP1

Protein Function

SUN2 has several biochemical functions, for example, identical protein binding,lamin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUN2 itself. We selected most functions SUN2 had, and list some proteins which have the same functions with SUN2. You can find most of the proteins on our site.

Function Related Protein
protein binding TRAF6,NCOA1,SETBP1,DCBLD2,KIF22,UNC45A,PLGRKT,BLOC1S4,WBP1,KLHL12
lamin binding IFI27,SYNE1,NARF,BNIP3L,PKP1,TOR1AIP1,TMPO,LBR,SUN1,PPP4C
identical protein binding BLOC1S6,PKD2,NFKBIA,SERPINB1A,C1QTNF9,CEACAM5,G6PDX,NELL2,MIEF1,ALCAMB

Interacting Protein

SUN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUN2.

Traf1

Resources

References

  • Randles, KN; Lam, L; et al. Nesprins, But Not Sun Proteins, Switch Isoforms at the Nuclear Envelope During Muscle Development. DEVELOPMENTAL DYNAMICS 239:998-1009(2010).
  • Hodzic, DM; Yeater, DB; et al. Sun2 is a novel mammalian inner nuclear membrane protein. JOURNAL OF BIOLOGICAL CHEMISTRY 279:25805-25812(2004).
  • Varas, J; Graumann, K; et al. Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination. PLANT JOURNAL 81:329-346(2015).

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