Recombinant Human STX1A

Cat.No. : STX1A-214H
Product Overview : Recombinant syntaxin 1A protein(1-226aa) contains N-terminal domain(Habc) and t_SNARE domain(H3 domain) and this protein was overexpressed in E.coli and purified by using the conventional column chromatography techniques.
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Species : Human
Source : E.coli
Tag : Non
Protein Length : 1-226 a.a.
Description : This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Form : In 20mM Tris (pH 7.5), 1mM DTT, 10% glycerol
Molecular Mass : 26.1 kDa (226 aa), confirmed by MALDI-TOF.
AA Sequence : MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQ
Purity : > 95% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name STX1A syntaxin 1A (brain) [ Homo sapiens (human) ]
Official Symbol STX1A
Synonyms STX1A; syntaxin 1A (brain); STX1; HPC-1; p35-1; STX1A; Syntaxin-1A; Neuron-specific antigen HPC-1
Gene ID 6804
mRNA Refseq NM_004603
Protein Refseq NP_004594
MIM 186590
UniProt ID Q16623
Chromosome Location 7q11.23
Pathway Acetylcholine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation
Function ATP-dependent protein binding; SNAP receptor activity; calcium channel inhibitor activity

Not For Human Consumption!

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