Recombinant Human STAT2
| Cat.No. : | STAT2-30904TH |
| Product Overview : | Recombinant full length protein (Human) |
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| Description : | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Form : | Liquid |
| Purity : | >90% by SDS-PAGE |
| Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequence Similarities : | Belongs to the transcription factor STAT family.Contains 1 SH2 domain. |
| Tag : | Non |
| Full Length : | Full L. |
| Gene Name | STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ] |
| Official Symbol | STAT2 |
| Synonyms | STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; |
| Gene ID | 6773 |
| mRNA Refseq | NM_005419 |
| Protein Refseq | NP_005410 |
| MIM | 600556 |
| Uniprot ID | P52630 |
| Chromosome Location | 12q13.2 |
| Pathway | Adipogenesis, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; |
| Function | DNA binding; calcium ion binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; |
Not For Human Consumption!
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