Recombinant Human STAT2 Protein, His-tagged

• Cat.No.: STAT2-151H
• Product Overview: Recombinant Human signal transducer and activator of transcription 2(STAT2) protein, transcript variant 1(NM_005419), with a His tag, was expressed in human cells.

Specification

• Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Human Cells
• Species: Human
• Tag: His
• Form: Purified protein formulated in a sterile solution of TBS buffer, pH7.35, without any preservatives.
• Molecular Mass: 97.7 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.

Gene Information

• Gene Name: STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ]
• Official Symbol: STAT2
• Synonyms: STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816
• Gene ID: 6773
• mRNA Refseq: NM_005419
• Protein Refseq: NP_005410
• MIM: 600556
• UniProt ID: P52630

Reviews

11/17/2022

Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

08/20/2017

The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

10/02/2016

Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

Q&As

How is the expression of STAT2 protein altered in certain diseases?

STAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.

Are there any known genetic mutations associated with STAT2-related disorders?

Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.

In what ways can the study of STAT2 protein aid in the development of novel immunotherapies?

Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.

Can the assessment of STAT2 expression levels serve as a prognostic marker for certain viral infections?

Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.

How do polymorphisms in the STAT2 gene influence individual susceptibility to infectious diseases?

Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.