Recombinant Human SPO11 cell lysate

• Cat.No.: SPO11-1684HCL

Specification

• Species: Human
• Tag: Non
• Description: Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5 end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: SPO11 SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: SPO11
• Synonyms: SPO11; SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); SPO11 meiotic protein covalently bound to DSB like (S. cerevisiae) , SPO11, meiotic protein covalently bound to DSB (S. cerevisiae) like; meiotic recombination protein SPO11; cancer/testis antigen 35; CT35; MGC39953
• Gene ID: 23626
• mRNA Refseq: NM_012444
• Protein Refseq: NP_036576
• MIM: 605114
• UniProt ID: Q9Y5K1
• Chromosome Location: 20q13.31
• Pathway: Meiosis, organism-specific biosystem; Meiotic Recombination, organism-specific biosystem
• Function: ATP binding; DNA binding; catalytic activity; hydrolase activity