Recombinant Human SP140 protein, His & T7-tagged

• Cat.No.: SP140-1467H
• Product Overview: Recombinant Human SP140 aa. (Gly443~Met655 (Accession # Q13342)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Gly443~Met655
• Description: This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 27.9kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 10.3

Gene Information

• Gene Name: SP140 SP140 nuclear body protein [ Homo sapiens (human) ]
• Official Symbol: SP140
• Synonyms: SP140; SP140 nuclear body protein; LYSP100; LYSP100-A; LYSP100-B; nuclear body protein SP140; lymphoid-restricted homolog of Sp100; lymphoid-specific SP100 homolog; nuclear autoantigen Sp-140; speckled 140 kDa
• Gene ID: 11262
• mRNA Refseq: NM_001005176.2
• Protein Refseq: NP_001005176.1
• UniProt ID: Q13342