Recombinant Human SP140, His&FLAG-tagged

• Cat.No.: SP140-76H
• Product Overview: Recombinant Human SP140 corresponding to amino acids 688-862 that contains the bromodomain sequences of SP140 (accession number NP_009168.4) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 26.98 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag&His
• Protein Length: 688-862 a.a.
• Description: SP140 nuclear body protein (SP140) is a component of the nuclear body that may be involved in trafficking between the nucleus and the cytoplasm. SP140 contains one HSR domain, one PHD-type zinc finger, a bromodomain and one SAND domain. The bromodomain functions as a "reader" of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. SP140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
• Form: 25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol.
• Applications: Binding assays, inhibitor screening, and selectivity profiling.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 3.2 mg/ml

Gene Information

• Gene Name: SP140 SP140 nuclear body protein [ Homo sapiens ]
• Official Symbol: SP140
• Synonyms: SP140; SP140 nuclear body protein; nuclear body protein SP140; LYSP100 A; LYSP100 B; speckled 140 kDa; nuclear autoantigen Sp-140; lymphoid-specific SP100 homolog; lymphoid-restricted homolog of Sp100; LYSP100; LYSP100-A; LYSP100-B; MGC126440
• Gene ID: 11262
• mRNA Refseq: NM_001005176
• Protein Refseq: NP_001005176
• MIM: 608602
• UniProt ID: Q13342
• Chromosome Location: 2q37.1
• Function: DNA binding; binding; metal ion binding; sequence-specific DNA binding transcription factor activity; zinc ion binding