Recombinant Human SNAP-associated Protein

• Cat.No.: SNAPIN-307H
• Product Overview: Recombinant Human SNAPAP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (156 aa, 17kDa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: SNAPAP (SNAP associated protein) was enriched in neurons and exclusively located on synaptic vesicle membrane protein. SNAPAP is an important component of the neurotransmitter release process through its modulation of the sequential interactions between the SNAREs and synaptotagmin, which is a component of the SNARE complex that is required for synaptic vesicle docking and fusion.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 5 mM DTT, 2 mM EDTA, 0.2 M NaCl, 40% glycerol.
• Molecular Weight: 17 kDa (156aa).
• Purity: > 90% by SDS – PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Sequence: MGSSHHHHHH SSGLVPRGSH MAGAGSAAVS GAGTPVAGPT GRDLFAEGLL EFLRPAVQQL DSHVHAVRES QVELREQIDN LATELCRINE DQKVALDLDP YVKKLLNARR RVVLVNNILQ NAQERLRRLN HSVAKETARR RAMLDSGIYP PGSPGK
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SNAPIN
• Synonyms: SNAPIN; SNAP-associated protein; SNAPAP; SNAP25BP; OTTHUMP00000035157; SNAP-25-binding protein; SNAP-associated protein; SNARE associated protein snapin; Synaptosomal-associated protein 25-binding protein.
• Gene ID: 23557
• mRNA Refseq: NM_012437.4
• Protein Refseq: NP_036569.1
• MIM: 607007
• UniProt ID: O95295
• Chromosome Location: 1q21.3
• Function: SNARE binding.