SNAPIN
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Official Full Name
SNAP-associated protein -
Overview
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble;N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis;of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of;the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1;complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules.;Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of;Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. -
Synonyms
SNAPIN;SNAP-associated protein;SNAPAP;SNARE-associated protein Snapin;SNAP 25 binding protein;SNAP-25-binding protein;SNARE associated protein snapin;synaptosomal-associated protein 25-binding protein
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
SNAPIN involved in several pathways and played different roles in them. We selected most pathways SNAPIN participated on our site, such as Clathrin derived vesicle budding,Golgi Associated Vesicle Biogenesis,Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNAPIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Clathrin derived vesicle budding | DTNBP1,BLOC1S3,GAK,CNO,CLTB,YIPF6,TFR1B,NAPAA,CTSZ,BLOC1S1 |
| Vesicle-mediated transport | CX27.5,TRAPPC2,FTH1A,CPD,CLVS1,HYOU1,CNO,PICALMA,LOC479668,NAPG |
| trans-Golgi Network Vesicle Budding | DTNBP1,CPD,TPD52,TBC1D8B,PUM1,DTNBP1B,SH3D19,CLINT1,CNO,NECAP1 |
| Membrane Trafficking | TPD52L1,TRAPPC3,LMAN2L,SEC22A,GJD3,TRAPPC10,STXBP3,MCFD2,BLOC1S1,TMED2 |
| Golgi Associated Vesicle Biogenesis | SNX9,BLOC1S4,NAPAB,PLDN,SH3D19,BLOC1S6,GAK,AP1S3A,SNX9A,AP1S1 |
Protein Function
SNAPIN has several biochemical functions, for example, SNARE binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNAPIN itself. We selected most functions SNAPIN had, and list some proteins which have the same functions with SNAPIN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF614,ZYX,ITGA1,TTC9C,GAD2,BUB1B,UBL4A,TRIB3,SVIP,CCDC93 |
| SNARE binding | EXOC3L,VAMP2,TNFAIP2A,GOSR2,STX4,VTI1A,STX1A,STX5AL,SYT1,STX11A |
Interacting Protein
SNAPIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNAPIN here. Most of them are supplied by our site. Hope this information will be useful for your research of SNAPIN.
BLOC1S2;DTNBP1;LRRK2;Slc14a2
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