Recombinant Human SMURF2, GST-tagged
Cat.No. : | SMURF2-138H |
Product Overview : | Recombinant human SMURF2 (amino acid residues 1-748), with N-terminal GST, was expressed in E.coli. |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Protein Length : | 1-748 a.a. |
Description : | The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s), conjugating enzymes (E2s) and protein ligases (E3s). Smad-Specific E3 Ubiquitin Protein Ligase 1 (SMURF2) is a member of the E3 protein ligase family and cloning of the human gene was first described by Kavsak et al. (2000). SMURF2 is a HECT domain ubiquitin E3 ligase that has been shown to regulate cell polarity, senescence and tumor suppression (Blank et al., 2012). |
Form : | 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol |
Molecular Mass : | ~114kDa |
Storage : | 12 months at -70°C. Avoid multiple freeze/thaw cycles. |
Concentration : | 0.5mg/ml |
Gene Name | SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ Homo sapiens ] |
Official Symbol | SMURF2 |
Synonyms | SMURF2; SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; E3 ubiquitin ligase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; MGC138150; DKFZp686F0270; |
Gene ID | 64750 |
mRNA Refseq | NM_022739 |
Protein Refseq | NP_073576 |
MIM | 605532 |
UniProt ID | Q9HAU4 |
Chromosome Location | 17q22-q23 |
Pathway | Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Endocytosis, organism-specific biosystem; |
Function | SMAD binding; acid-amino acid ligase activity; identical protein binding; ligase activity; protein binding; ubiquitin-protein ligase activity; |
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Not For Human Consumption!
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