SMURF2
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Official Full Name
SMAD specific E3 ubiquitin protein ligase 2 -
Overview
SMURF2 has been shown to interact with Mothers against decapentaplegic homolog 7, SCYE1, SMURF1, Mothers against decapentaplegic homolog 3, Ubiquitin C, Mothers against decapentaplegic homolog 1 and Mothers against decapentaplegic homolog 2. -
Synonyms
SMURF2;SMAD specific E3 ubiquitin protein ligase 2;E3 ubiquitin-protein ligase SMURF2;hSMURF2;E3 ubiquitin ligase SMURF2;SMAD ubiquitination regulatory factor 2;SMAD-specific E3 ubiquitin-protein ligase 2;MGC138150;DKFZp686F0270
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Sf9 Cells
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Flag
- His
- GST
- Non
- Avi&Fc&His
- DDK&Myc
Involved Pathway
SMURF2 involved in several pathways and played different roles in them. We selected most pathways SMURF2 participated on our site, such as Ubiquitin mediated proteolysis,Endocytosis,TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMURF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | SMAD3,TFDP1,CUL1,NODAL,MAPK1,ID4,CHD,GDF7,RPS6KB1,NDR1 |
| Endocytosis | STAMBPA,DNM1B,RNF103-CHMP3,WASL,PARD6GB,GRK1,ZFYVE16,PRKCI,HSPA1A,CYTH4 |
| Ubiquitin mediated proteolysis | COP1,HERC3,SAE1,RBX1,UBE4B,UBE2G1A,UBE2L3A,BIRC7,PML,ANAPC13 |
Protein Function
SMURF2 has several biochemical functions, for example, SMAD binding,identical protein binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMURF2 itself. We selected most functions SMURF2 had, and list some proteins which have the same functions with SMURF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | FEM1A,RNF144AB,RNF41,UBE2H,UHRF1,NHLRC1,TRIM23,MARCH8,G2E3,TRAF2 |
| protein binding | ABCB9,O3far1,SEMG1,ARFGAP3,TBC1D22B,RUNDC3A,POLE4,ILVBL,TSSK2,TBCA |
| ubiquitin protein ligase activity | FBXO6,UBE3A,ITCHA,SIAH2,UBE2J2,UBR5,UBE2KB,RNF144B,RNF139,MED10 |
| SMAD binding | CTNNB1,FKBP1A,SMAD2,HIPK2,TOB1,SNW1,SKI,TGFBR2,SKOR1,SKIB |
| identical protein binding | IAPP,TMEM115,AGXT2,NFKBIA,MYOM1,SOX10,SHANK1,ETNPPL,DIAPH1,GLE1 |
| transforming growth factor beta receptor binding | LRG1,SMAD2,NODAL,INHA,BMP8A,BMP4,BMP3,LEFTY2,GDF6,GDF2 |
| ligase activity | TRIM17,RCHY1,UBE2G1B,PIAS1,UHRF1,COP1,ZFP91,LIPT2,MUL1A,HECTD3 |
Interacting Protein
SMURF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMURF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMURF2.
SMAD2;RNF11;SMAD3
SMURF2 Related Signal Pathway
Resources
Research Area
Ubiquitin-related Molecules in the Akt PathwayE3 Ubiquitin Ligases
Negative Regulators of EMT
Related Services
Related Products
References
- Verma, NK; Dempsey, E; et al. Leukocyte Function-associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction Induces a Novel Genetic Signature Resulting in T-cells Refractory to Transforming Growth Factor-beta Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 287:27204-27216(2012).
- Sun, Y; Zhou, MM; et al. Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells. EXPERIMENTAL LUNG RESEARCH 37:568-573(2011).
