Recombinant Human SMC3, GST-tagged

Description :	This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
Source :	Wheat germ
Species :	Human
Tag :	GST
Molecular Mass :	36.63 kDa
AA Sequence :	IDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDL LSQLSLEDQKRVDALNDEIRQLQQE
Applications :	ELISA; WB-Re; AP; Array
Notes :	Best use within three months from the date of receipt of this protein.
Storage :	Store at -80ºC. Aliquot to avoid repeated freezing and thawing.
Storage Buffer :	50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Name	SMC3 structural maintenance of chromosomes 3 [ Homo sapiens (human) ]
Official Symbol	SMC3
Synonyms	SMC3; structural maintenance of chromosomes 3; chondroitin sulfate proteoglycan 6 (bamacan) , CSPG6; structural maintenance of chromosomes protein 3; BAM; bamacan; bamacan proteoglycan; HCAP; SMC3L1; SMC-3; SMC protein 3; chromosome-associated polypeptide; chondroitin sulfate proteoglycan 6 (bamacan); basement membrane-associated chondroitin proteoglycan; BMH; CDLS3; CSPG6
Gene ID	9126
mRNA Refseq	NM_005445
Protein Refseq	NP_005436
MIM	606062
UniProt ID	Q9UQE7
Chromosome Location	10q25
Pathway	Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Mitotic Prometaphase; Oocyte meiosis
Function	ATP binding; chromatin binding; mediator complex binding