Recombinant Human SMC3, His-tagged

• Cat.No.: SMC3-31196TH
• Product Overview: Recombinant fragment, corresponding to amino acids 233-736 of Human SMC3 with a N terminal His tag; predicted MWt 60 kDa:

Specification

• Description: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitution with 118 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: NETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIER QVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAK DLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETE PKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSK EERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEAN KEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDE LQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATG KAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFEC EPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMN LPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPR FDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKL NENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDS IL
• Sequence Similarities: Belongs to the SMC family. SMC3 subfamily.
• Protein length: 233-736 a.a.

Gene Information

• Gene Name: SMC3 structural maintenance of chromosomes 3 [ Homo sapiens ]
• Official Symbol: SMC3
• Synonyms: SMC3; structural maintenance of chromosomes 3; chondroitin sulfate proteoglycan 6 (bamacan) , CSPG6; structural maintenance of chromosomes protein 3; BAM; bamacan; bamacan proteoglycan; HCAP; SMC3L1
• Gene ID: 9126
• mRNA Refseq: NM_005445
• Protein Refseq: NP_005436
• MIM: 606062
• Uniprot ID: Q9UQE7
• Chromosome Location: 10q25
• Pathway: Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; DNA Replication, organism-specific biosystem; M Phase, organism-specific biosystem
• Function: ATP binding; dynein binding; microtubule motor activity; nucleotide binding; protein binding