Recombinant Human SMARCA2, GST-tagged

• Cat.No.: SMARCA2-159H
• Product Overview: Recombinant Human BRM bromodomain (1367-1511 aa) fused to a GST tag at the N-terminus

Specification

• Description: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRM is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
• Molecular Mass: 43.7 kDa (1367-1511 aa + NT GST Tag)
• Purity: ≥95%
• Storage: Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.
• Protein length: 1367-1511

Gene Information

• Gene Name: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [ Homo sapiens ]
• Official Symbol: SMARCA2
• Synonyms: SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SNF2L2; probable global transcription activator SNF2L2; BAF190; BRM; hBRM; hSNF2a; SNF2; SNF2LA; Sth1p; SWI2; BAF190B; SNF2-alpha; protein brahma homolog; SNF2/SWI2-like protein 2; BRG1-associated factor 190B; ATP-dependent helicase SMARCA2; sucrose nonfermenting 2-like protein 2; global transcription activator homologous sequence; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; FLJ36757; MGC74511
• Gene ID: 6595
• mRNA Refseq: NM_003070
• Protein Refseq: NP_003061
• MIM: 600014
• UniProt ID: P51531
• Chromosome Location: 9p24.3
• Pathway: C-MYB transcription factor network, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem
• Function: ATP binding; DNA binding; DNA-dependent ATPase activity; RNA polymerase II transcription coactivator activity; helicase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; nucleotide binding; protein binding; transcription coactivator activity; transcription regulatory region DNA binding