SMARCA2
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Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -
Overview
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma;protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate;transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of;the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of;genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this;gene, which contains a trinucleotide repeat (CAG) length polymorphism. -
Synonyms
SMARCA2;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2;SNF2L2;probable global transcription activator SNF2L2;BAF190;BRM;hBRM;hSNF2a;SNF2;SNF2LA;Sth1p;SWI2;BAF190B;SNF2-alpha;protein brahma h
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Insect Cells
- E.coli
- Mammalian Cells
- Yeast
- Flag
- His
- GST
- Non
- SUMO
- Avi
- MBP
Involved Pathway
SMARCA2 involved in several pathways and played different roles in them. We selected most pathways SMARCA2 participated on our site, such as C-MYB transcription factor network,Chromatin modifying enzymes,Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Androgen receptor activity | SRY,SPDEF,GATA2,NR2C1,NR2C2,SMARCE1,TRIM24,SENP1,APPBP2,KAT7 |
| C-MYB transcription factor network | LECT2,GATA1,SKI,CSF1R,PPID,PTCRA,CEBPB,CDKN1B,CBX4,CLTA |
| Chromatin modifying enzymes | RBBP7,KAT8,KDM5BB,USP22,PRMT5,VPS72,C3orf75,DPY30,ARID5B,ANO9A |
| Chromatin organization | SMARCB1A,CHD4,SAP30,KAT8,ACTL6B,C3orf75,EPC1,BRPF3,SETD3,EHMT2 |
| RB in Cancer | PRMT2,HLTF,RBP1,HMGB2,DCK,FAF1,RABIF,TOP2A,ANLN |
| RMTs methylate histone arginines | SMARCC1B,SMARCC1,SMARCB1B,SMARCB1A,SMARCA4,WDR77,SMARCB1,ARID2,ACTL6B,COPRS |
| E2F transcription factor network | PRMT5,MYBL2,CEBPA,CES1,E2F4,HIC1,RBBP8,CBX5,YY1,UXT |
Protein Function
SMARCA2 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCA2 itself. We selected most functions SMARCA2 had, and list some proteins which have the same functions with SMARCA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | C22orf28,KIF7,UBE2D1B,GUCY2C,KIF6,FGFR1,SNRKB,PRKACAA,HSPA5,CSF1R |
| histone binding | SMARCA4A,USP16,SET,HIST1H4M,HIST1H3H,PIH1D1,PRKCBP1L,PRKCBB,CHAF1B,HIST1H3C |
| transcription regulatory region DNA binding | RELA,BCOR,WNT5A,GRHL1,RNF10,ARID5B,THRA,IKZF3,HIVEP3,BCL11AB |
| chromatin binding | GLI1,ERCC6,SUPT5H,RAG2,TOP2A,ATAD2,CBFA2T3,SALL1,NR5A1,UBE2T |
| RNA polymerase II transcription coactivator activity | MKL1B,CITED1,MED12L,ISL1,PRRX1,SOX11,CITED4,MKL1,POU1F1,TRIM28 |
| transcription coactivator activity | GMEB2,YAP1,NCOA2,PML,GRIP1,MCIN,KLF7,TAF10,TAF1,NRIP1 |
| protein binding | STK16,ANXA1,FHOD1,ZFP161,C19orf47,PINK1,HIST1H2AI,AGR2,SPANXA1,SYNJ2 |
| DNA-dependent ATPase activity | MSH4,CDK7,CHD8,RAD51L3,XRCC2,XRCC3,MSH5,SMARCAL1,TOP2A,ERCC2 |
| helicase activity | WRN,RAD54L,ERCC6L,DQX1,NAV2,SMARCAL1,DDX6,BLM,TDRD9,MCM8 |
Interacting Protein
SMARCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCA2.
tat_hv112;ARID1A;ARID1B;MECP2;KHDRBS1
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References
- Lee, D; Moon, S; et al. NMR and Fluorescence Studies of DNA Binding Domain of INI1/hSNF5. BULLETIN OF THE KOREAN CHEMICAL SOCIETY 35:2753-2757(2014).
- Zhang, LY; Ma, P; et al. Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. MOLECULAR VISION 20:56-72(2014).
