Recombinant Human Small Nuclear Ribonucleoprotein Polypeptide C, His-tagged

• Cat.No.: SNRPC-1323H
• Product Overview: Recombinant human SNRPC protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Specification

• Cat. No.: SNRPC-1323H
• Description: SNRPC belongs to the U1 small nuclear ribonucleoprotein C family. This protein component of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. This protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 5 mM DTT, 50% glycerol, 0.3 M NaCl, 2 mM EDTA.
• Molecular Weight: 19.8 kDa (182 aa) confirmed by MALDI-TOF
• Purity: > 85 % by SDS-PAGE
• Concentration: 0.25 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSMPKFYCD YCDTYLTHDS PSVRKTHCSG RKHKENVKDY YQKWMEEQAQ SLIDKTTAAF QQGKIPPTPF SAPPPAGAMI PPPPSLPGPP RPGMMPAPHM GGPPMMPMMG PPPPGMMPVG PAPGMRPPMG GHMPMMPGPP MMRPPARPMM VPTRPGMTRP DR
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Spliceosome

Gene Information

• Gene Name: SNRPC small nuclear ribonucleoprotein polypeptide C [ Homo sapiens ]
• Official Symbol: SNRPC
• Synonyms: SNRPC; small nuclear ribonucleoprotein polypeptide C; U1C; Yhc1; FLJ20302; U1 small nuclear ribonucleoprotein C; U1 snRNP C; OTTHUMP00000016238; OTTHUMP00000016239; OTTHUMP00000016240; U1 snRNP protein C; U1 small nuclear RNP specific C
• Gene ID: 6631
• mRNA Refseq: NM_003093
• Protein Refseq: NP_003084
• MIM: 603522
• UniProt ID: P09234
• Chromosome Location: 6p21
• Function: RNA binding; NOT U1 snRNA binding; metal ion binding; nucleic acid binding; protein binding; protein homodimerization activity; single-stranded RNA binding; zinc ion binding