Recombinant Human SMAD6 Protein, His-tagged

• Cat.No.: PGC-299H
• Product Overview: Recombinant Human SMAD6(Cys261~Pro495) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 29.7kDa
• Protein length: Cys261~Pro495
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: SMAD6 SMAD family member 6 [ Homo sapiens ]
• Official Symbol: SMAD6
• Synonyms: SMAD6; SMAD family member 6; MAD, mothers against decapentaplegic homolog 6 (Drosophila) , MADH6, MADH7, SMAD, mothers against DPP homolog 6 (Drosophila); mothers against decapentaplegic homolog 6; HsT17432; SMAD 6; hSMAD6; MAD homolog 6; mothers against DPP homolog 6; SMAD, mothers against DPP homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6; MADH6; MADH7
• Gene ID: 4091
• mRNA Refseq: NM_001142861
• Protein Refseq: NP_001136333
• MIM: 602931
• UniProt ID: O43541